Ontology highlight
ABSTRACT:
SUBMITTER: Polydorou C
PROVIDER: S-EPMC5421866 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Polydorou Christiana C Mpekris Fotios F Papageorgis Panagiotis P Voutouri Chrysovalantis C Stylianopoulos Triantafyllos T
Oncotarget 20170401 15
Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion and thus, improve drug delivery and the efficacy of cancer therapy. Therefore, we now need to identify safe and well tolerated pharmaceutical agents that are able to remodel the microenvironment of solid tumors and enhance chemotherapy. In this study, we repurposed Pirfenidon ...[more]