Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC5421875 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Jin Yuanyuan Y Li Linhu L Yang Zhaoyong Z Liu Mingliang M Guo Huiyuan H Shen Weiyi W
Oncotarget 20170401 15
Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual screening. It exhibits stronger potency (IC50s: 6.92-8.99 μM) than Sunitinib against all of the tested cancer cell lines. Preliminary studies on mechanism reveal that IMB-1406 induces apoptosis in HepG2 cells by arresting the cell cycle at t ...[more]