Ontology highlight
ABSTRACT:
SUBMITTER: Omarjee S
PROVIDER: S-EPMC5422711 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Omarjee S S Jacquemetton J J Poulard C C Rochel N N Dejaegere A A Chebaro Y Y Treilleux I I Marangoni E E Corbo L L Romancer M Le ML
Oncogene 20161212 18
Alterations in estrogen-mediated cellular signaling have largely been implicated in the pathogenesis of breast cancer. Here, we investigated the signaling regulation of a splice variant of the estrogen receptor, namely estrogen receptor (ERα-36), associated with a poor prognosis in breast cancers. Coupling in vitro and in vivo approaches we determined the precise sequential molecular events of a new estrogen signaling network in an ERα-negative cell line and in an original patient-derived xenogr ...[more]