Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC5422804 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170410 18
Modern immunochemical engineering allows the creation of cells that either secrete antibodies or incorporate them into various cellular compartments, including the plasma membrane. Because the receptors for most viruses are known, if one can achieve the proper stoichiometry and geometry, plasma membrane-associated antibodies to these receptors should block viral infection. In this report, we test this concept for two different viruses, human rhinovirus and HIV. Plasma membrane-tethered antibodie ...[more]