Ontology highlight
ABSTRACT:
SUBMITTER: Hasvold G
PROVIDER: S-EPMC5423158 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Hasvold Grete G Lund-Andersen Christin C Lando Malin M Patzke Sebastian S Hauge Sissel S Suo ZhenHe Z Lyng Heidi H Syljuåsen Randi G RG
Molecular oncology 20160108 5
Hypoxia promotes an aggressive tumor phenotype with increased genomic instability, partially due to downregulation of DNA repair pathways. However, genome stability is also surveilled by cell cycle checkpoints. An important issue is therefore whether hypoxia also can influence the DNA damage-induced cell cycle checkpoints. Here, we show that hypoxia (24 h 0.2% O2) alters the expression of several G2 checkpoint regulators, as examined by microarray gene expression analysis and immunoblotting of U ...[more]