Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort.
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SUBMITTER: Gupta VB
PROVIDER: S-EPMC5423327 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort.
Gupta Veer Bala VB Hone Eugene E Pedrini Steve S Doecke James J O'Bryant Sid S James Ian I Bush Ashley I AI Rowe Christopher C CC Villemagne Victor L VL Ames David D Masters Colin L CL Martins Ralph N RN
Alzheimer's & dementia (Amsterdam, Netherlands) 20170423
<h4>Introduction</h4>A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing.<h4>Methods</h4>We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort.<h4>Results</h4>Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (<i>P</i> = . ...[more]
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