Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.
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ABSTRACT:
SUBMITTER: Matsu-Ura T
PROVIDER: S-EPMC5423461 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.
Matsu-Ura Toru T Dovzhenok Andrey A Aihara Eitaro E Rood Jill J Le Hung H Ren Yan Y Rosselot Andrew E AE Zhang Tongli T Lee Choogon C Obrietan Karl K Montrose Marshall H MH Lim Sookkyung S Moore Sean R SR Hong Christian I CI
Molecular cell 20161117 5
Circadian clock-gated cell division cycles are observed from cyanobacteria to mammals via intracellular molecular connections between these two oscillators. Here we demonstrate WNT-mediated intercellular coupling between the cell cycle and circadian clock in 3D murine intestinal organoids (enteroids). The circadian clock gates a population of cells with heterogeneous cell-cycle times that emerge as 12-hr synchronized cell division cycles. Remarkably, we observe reduced-amplitude oscillations of ...[more]
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