The seven faces of SIRT7.
Ontology highlight
ABSTRACT:
SUBMITTER: Blank MF
PROVIDER: S-EPMC5423475 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
SIRT7, a member of the sirtuin family of NAD<sup>+</sup>-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functi ...[more]
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