Ontology highlight
ABSTRACT:
SUBMITTER: Chung W
PROVIDER: S-EPMC5424158 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chung Woosung W Eum Hye Hyeon HH Lee Hae-Ock HO Lee Kyung-Min KM Lee Han-Byoel HB Kim Kyu-Tae KT Ryu Han Suk HS Kim Sangmin S Lee Jeong Eon JE Park Yeon Hee YH Kan Zhengyan Z Han Wonshik W Park Woong-Yang WY
Nature communications 20170505
Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of heterogeneous tumour cells along with neighbouring stromal and immune cells. Here we adopt this powerful approach to breast cancer and analyse 515 cells from 11 patients. Inferred copy number variations from the single-cell RNA-seq data separate carcinoma cells from non-cancer cells. At a single-cell resolution, carcinoma cells display common signatures within the tumour as well as intratumoral heterogen ...[more]