The Microenvironmental Landscape of Brain Tumors.
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ABSTRACT:
SUBMITTER: Quail DF
PROVIDER: S-EPMC5424263 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
The Microenvironmental Landscape of Brain Tumors.
Quail Daniela F DF Joyce Johanna A JA
Cancer cell 20170301 3
The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TM ...[more]
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