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The Microenvironmental Landscape of Brain Tumors.


ABSTRACT: The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.

SUBMITTER: Quail DF 

PROVIDER: S-EPMC5424263 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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The Microenvironmental Landscape of Brain Tumors.

Quail Daniela F DF   Joyce Johanna A JA  

Cancer cell 20170301 3


The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TM  ...[more]

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