Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies.

ABSTRACT: Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown.We analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses' Health Study (NHS), and in 5648 women from the Women's Health Initiative (WHI). The genetic risk score was calculated based on 77 BMI-associated loci. Coffee consumption was examined prospectively in relation to BMI.The genetic association with BMI was attenuated among participants with higher consumption of coffee than among those with lower consumption in the HPFS (P interaction ?=?0.023) and NHS (P interaction ?=?0.039); similar results were replicated in the WHI (P interaction ?=?0.044). In the combined data of all cohorts, differences in BMI per increment of 10-risk allele were 1.38 (standard error (SE), 0.28), 1.02 (SE, 0.10), and 0.95 (SE, 0.12) kg/m2 for coffee consumption of??3 cup(s)/day, respectively (P interaction ?

SUBMITTER: Wang T 

PROVIDER: S-EPMC5424298 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature