Ontology highlight
ABSTRACT:
SUBMITTER: Kesarwani M
PROVIDER: S-EPMC5424814 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kesarwani Meenu M Kincaid Zachary Z Gomaa Ahmed A Huber Erika E Rohrabaugh Sara S Siddiqui Zain Z Bouso Muhammad F MF Latif Tahir T Xu Ming M Komurov Kakajan K Mulloy James C JC Cancelas Jose A JA Grimes H Leighton HL Azam Mohammad M
Nature medicine 20170320 4
Tyrosine-kinase inhibitor (TKI) therapy for human cancers is not curative, and relapse occurs owing to the continued presence of tumor cells, referred to as minimal residual disease (MRD). The survival of MRD stem or progenitor cells in the absence of oncogenic kinase signaling, a phenomenon referred to as intrinsic resistance, depends on diverse growth factors. Here we report that oncogenic kinase and growth-factor signaling converge to induce the expression of the signaling proteins FBJ osteos ...[more]