Ontology highlight
ABSTRACT:
SUBMITTER: Goodchild SC
PROVIDER: S-EPMC5425669 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Goodchild Sophia C SC Curmi Paul M G PMG Brown Louise J LJ
Biophysical reviews 20110728 3
The classic structure-function paradigm holds that a protein exhibits a single well-defined native state that gives rise to its biological function. Nonetheless, over the past few decades, numerous examples of proteins exhibiting biological function arising from multiple structural states of varying disorder have been identified. Most recently, several examples of 'metamorphic proteins', able to interconvert between vastly different native-like topologies under physiological conditions, have bee ...[more]