Ontology highlight
ABSTRACT:
SUBMITTER: Iizuka-Koga M
PROVIDER: S-EPMC5425788 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Iizuka-Koga Mana M Asashima Hiromitsu H Ando Miki M Lai Chen-Yi CY Mochizuki Shinji S Nakanishi Mahito M Nishimura Toshinobu T Tsuboi Hiroto H Hirota Tomoya T Takahashi Hiroyuki H Matsumoto Isao I Otsu Makoto M Sumida Takayuki T
Stem cell reports 20170501 5
Although it is important to clarify the pathogenic functions of T cells in human samples, their examination is often limited due to difficulty in obtaining sufficient numbers of dendritic cells (DCs), used as antigen-presenting cells, especially in autoimmune diseases. We describe the generation of DCs from induced pluripotent stem cells derived from T cells (T-iPSCs). We reprogrammed CD4+ T cell clones from a patient with Sjögren's syndrome (SS) into iPSCs, which were differentiated into DCs (T ...[more]