Ontology highlight
ABSTRACT:
SUBMITTER: Ho HY
PROVIDER: S-EPMC5426036 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ho Hung-Yao HY Lin Yu-Ting YT Lin Gigin G Wu Pei-Ru PR Cheng Mei-Ling ML
Redox biology 20170429
To study the physiological roles of NADH and NADPH homeostasis in cancer, we studied the effect of NNT knockdown on physiology of SK-Hep1 cells. NNT knockdown cells show limited abilities to maintain NAD<sup>+</sup> and NADPH levels and have reduced proliferation and tumorigenicity. There is an increased dependence of energy production on oxidative phosphorylation. Studies with stable isotope tracers have revealed that under the new steady-state metabolic condition, the fluxes of TCA and glycoly ...[more]