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Demographic, lifestyle, and other factors in relation to antimullerian hormone levels in mostly late premenopausal women.

ABSTRACT: OBJECTIVE:To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. DESIGN:Cross-sectional study. SETTING:Not applicable. PATIENT(S):A total of 671 premenopausal women not known to have cancer. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. RESULT(S):Older women had significantly lower AMH concentrations (?40 [n = 444] vs. <35 years [n = 64], multivariable-adjusted median 0.73 ng/mL vs. 2.52 ng/mL). Concentrations of AMH were also significantly lower among women with earlier age at menarche (<12 [n = 96] vs. ?14 years [n = 200]: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n = 27) compared with never or former users (n = 468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity, and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). CONCLUSION(S):Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche, and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles.

SUBMITTER: Jung S

PROVIDER: S-EPMC5426228 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women.

Jung Seungyoun S Allen Naomi N Arslan Alan A AA Baglietto Laura L Brinton Louise A LA Egleston Brian L BL Falk Roni R Fortner Renée T RT Helzlsouer Kathy J KJ Idahl Annika A Kaaks Rudolph R Lundin Eva E Merritt Melissa M Onland-Moret Charlotte C Rinaldi Sabina S Sánchez María-José MJ Sieri Sabina S Schock Helena H Shu Xiao-Ou XO Sluss Patrick M PM Staats Paul N PN Travis Ruth C RC Tjønneland Anne A Trichopoulou Antonia A Tworoger Shelley S Visvanathan Kala K Krogh Vittorio V Weiderpass Elisabete E Zeleniuch-Jacquotte Anne A Zheng Wei W Dorgan Joanne F JF

Fertility and sterility 20170401 4

<h4>Objective</h4>To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>A total of 671 premenopausal women not known to have cancer.<h4>Intervention(s)</h4>None.<h4>Main outcome measure(s)</h4>Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median ...[more]

PMID: 28366409

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Project description:PurposeMenstrual cycle characteristics are markers of endocrine milieu. However, associations between age at menarche and adulthood sex steroid hormone levels have been inconsistent, and data on menstrual characteristics and non-sex steroid hormones are sparse.MethodsWe assessed the relations of menstrual characteristics with premenopausal plasma sex steroid hormones, sex hormone binding globulin (SHBG), prolactin, and growth factors among 2,745 premenopausal women (age 32-52) from the Nurses' Health Study II. Geometric means and tests for trend were calculated using multivariable general linear models.ResultsEarly age at menarche was associated with higher premenopausal early-follicular free estradiol (percent difference < 12 vs. > 13 years = 11%), early-follicular estrone (7%), luteal estrone (7%), and free testosterone (8%) (all p trend < 0.05). Short menstrual cycle length at age 18-22 was associated with higher early-follicular total (< 26 vs. > 39 days = 18%) and free estradiol (16%), early-follicular estrone (9%), SHBG (7%), lower luteal free estradiol (- 14%), total (- 6%), and free testosterone (- 15%) (all p trend < 0.05). Short adult menstrual length was associated with higher early-follicular total estradiol (< 26 vs. > 31 days = 14%), SHBG (10%), lower luteal estrone (- 8%), progesterone (- 9%), total (- 11%) and free testosterone (- 25%), and androstenedione (- 14%) (all p trend < 0.05). Irregularity of menses at 18-22 was associated with lower early-follicular total (irregular vs. very regular = - 14%) and free estradiol (- 14%), and early-follicular estrone (- 8%) (All p trend < 0.05). Irregularity of adult menstrual cycle was associated with lower luteal total estradiol (irregular vs. very regular = - 8%), SHBG (- 3%), higher total (8%), and free testosterone (11%) (all p trend < 0.05).ConclusionsEarly-life and adulthood menstrual characteristics are moderately associated with mid-to-late reproductive year's hormone concentrations. These relations of menstrual characteristics with endogenous hormone levels could partially account for associations between menstrual characteristics and reproductive cancers or other chronic diseases.

Dataset Information

Demographic, lifestyle, and other factors in relation to antimullerian hormone levels in mostly late premenopausal women.

Publications

Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women.

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