Differentiation Potential of Mesenchymal Stem Cells Is Related to Their Intrinsic Mechanical Properties.

ABSTRACT:

Purpose

The differentiation properties of stem cells are not yet fully understood due to their close association with multiple environmental and extrinsic factors. This study investigates the differentiation properties of mesenchymal stem cells (MSCs) and correlates them with their intrinsic mechanical properties.

Methods

A total of 3 different types of MSCs, namely bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UCSCs), and adipose-derived MSCs (ADSCs) were evaluated. These 3 MSCs were individually differentiated into adipocytes and osteoblasts for 3 weeks. The mechanical properties of the MSCs and differentiated cells were determined by atomic force microscopy.

Results

ADSCs showed the greatest ability to differentiate into adipocytes, followed by BMS

SUBMITTER: Han I 

PROVIDER: S-EPMC5426435 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature