The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis.

ABSTRACT:

Background

H. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection.

Methods

A literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were determined eligible. Meta-analytical techniques were conducted to calculate eradication rates and pooled relative ratios (RR).

Results

The eradication rate was greater approximately 10% in vacA s1 compared with vacA s2 infected patients, and the pooled RR was 1.164 (95%CI: 1.040-1.303, P = 0.008). A significant association existed between vacA s1 and higher eradication rates in Eu

SUBMITTER: Wang D 

PROVIDER: S-EPMC5426689 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature