Ontology highlight
ABSTRACT:
SUBMITTER: Date SS
PROVIDER: S-EPMC5426777 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Date Swapneeta S SS Fiori Mariana C MC Altenberg Guillermo A GA Jansen Michaela M
PloS one 20170511 5
The proton-coupled folate transporter (PCFT) provides an essential uptake route for the vitamin folic acid (B9) in mammals. In addition, it is currently of high interest for targeting chemotherapeutic agents to tumors due to the increased folic acid requirement of rapidly dividing tumor cells as well as the upregulated PCFT expression in several tumors. To understand its function, determination of its atomic structure and molecular mechanism of transport are essential goals that require large am ...[more]