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Alzheimer's disease, dementia, and stem cell therapy.

ABSTRACT: Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.

SUBMITTER: Duncan T

PROVIDER: S-EPMC5427593 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Alzheimer's disease, dementia, and stem cell therapy.

Duncan Thomas T Valenzuela Michael M

Stem cell research & therapy 20170512 1

Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human ...[more]

PMID: 28494803

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