Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s.
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ABSTRACT:
SUBMITTER: Bhatia HS
PROVIDER: S-EPMC5428011 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE<sub>2</sub> Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s.
Bhatia Harsharan S HS Roelofs Nora N Muñoz Eduardo E Fiebich Bernd L BL
Scientific reports 20170308 1
Exaggerated inflammatory responses in microglia represent one of the major risk factors for various central nervous system's (CNS) associated pathologies. Release of excessive inflammatory mediators such as prostaglandins and cytokines are the hallmark of hyper-activated microglia. Here we have investigated the hitherto unknown effects of capsaicin (cap) - a transient receptor potential vanilloid 1 (TRPV1) agonist- in murine primary microglia, organotypic hippocampal slice cultures (OHSCs) and h ...[more]
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