Ontology highlight
ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC5428279 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Fan Ying Y Zhang Jing J Xiao Wenzhen W Lee Kyung K Li Zhengzhe Z Wen Jiejun J He Li L Gui Dingkun D Xue Rui R Jian Guihua G Sheng Xiaohua X He John Cijiang JC Wang Niansong N
Scientific reports 20170323 1
We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severity of kidney injury in patients with diabetic nephropathy (DN). Here, we determined the roles of RTN1A and ER stress in podocyte injury and DN. We used db/db mice with early unilateral nephrectomy (Unx) as a murine model of progressive DN and treated mice with tauroursodeoxycholic acid (TUD ...[more]