Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.
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ABSTRACT:
SUBMITTER: Guida F
PROVIDER: S-EPMC5428303 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.
Guida F F Luongo L L Boccella S S Giordano M E ME Romano R R Bellini G G Manzo I I Furiano A A Rizzo A A Imperatore R R Iannotti F A FA D'Aniello E E Piscitelli F F Sca Rossi F F Cristino L L Di Marzo V V de Novellis V V Maione S S
Scientific reports 20170323 1
The endogenous fatty acid amide palmitoylethanolamide (PEA) has been shown to exert anti-inflammatory actions mainly through inhibition of the release of pro-inflammatory molecules from mast cells, monocytes and macrophages. Indirect activation of the endocannabinoid (eCB) system is among the several mechanisms of action that have been proposed to underlie the different effects of PEA in vivo. In this study, we used cultured rat microglia and human macrophages to evaluate whether PEA affects eCB ...[more]
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