Ontology highlight
ABSTRACT:
SUBMITTER: Rupp LJ
PROVIDER: S-EPMC5428439 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Rupp Levi J LJ Schumann Kathrin K Roybal Kole T KT Gate Rachel E RE Ye Chun J CJ Lim Wendell A WA Marson Alexander A
Scientific reports 20170407 1
Immunotherapies with chimeric antigen receptor (CAR) T cells and checkpoint inhibitors (including antibodies that antagonize programmed cell death protein 1 [PD-1]) have both opened new avenues for cancer treatment, but the clinical potential of combined disruption of inhibitory checkpoints and CAR T cell therapy remains incompletely explored. Here we show that programmed death ligand 1 (PD-L1) expression on tumor cells can render human CAR T cells (anti-CD19 4-1BBζ) hypo-functional, resulting i ...[more]