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Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury.

ABSTRACT: Frequent and drastic ambient temperature variation may cause respiratory diseases such as common cold and pneumonia, the mechanism for which is not fully understood, however, due to lack of appropriate animal models. Ma-Huang-Tang (MHT) is widely used in China for treatment of respiratory diseases. The present study aimed to investigate the effect of MHT on temperature alternation induced rat lung injury and explore underlying mechanisms. Male Sprague-Dawley rats were exposed to a cold environment for 1?h and then shifted to a warm environment for 30?min. This cold and warm alteration cycled 4 times. Rats were administrated with MHT (1.87?g/kg) by gavage 6?h after cold-warm-cycles. Cold-warm-cycles induced pulmonary microcirculatory disorders, lung edema and injury, decrease in the expression of tight junction proteins, increase in VE-cadherin activation, increase in the expression and activation of Caveolin-1, Src and NF-?B, and NADPH oxidase subunits p47^phox, p40^phox and p67^phox membrane translocation and inflammatory cytokines production. All alterations were significantly ameliorated by post-treatment with MHT. This study showed that rats subjected to cold-warm-cycles may be used as an animal model to investigate ambient temperature variation-induced lung injury, and suggested MHT as a potential strategy to combat lung injury induced by temperature variation.

SUBMITTER: Xiao MM

PROVIDER: S-EPMC5428516 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury.

Xiao Meng-Meng MM Pan Chun-Shui CS Liu Yu-Ying YY Ma Li-Qian LQ Yan Li L Fan Jing-Yu JY Wang Chuan-She CS Huang Rong R Han Jing-Yan JY

Scientific reports 20170322 1

Frequent and drastic ambient temperature variation may cause respiratory diseases such as common cold and pneumonia, the mechanism for which is not fully understood, however, due to lack of appropriate animal models. Ma-Huang-Tang (MHT) is widely used in China for treatment of respiratory diseases. The present study aimed to investigate the effect of MHT on temperature alternation induced rat lung injury and explore underlying mechanisms. Male Sprague-Dawley rats were exposed to a cold environme ...[more]

PMID: 28331194

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Dataset Information

Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury.

Publications

Post-treatment with Ma-Huang-Tang ameliorates cold-warm-cycles induced rat lung injury.

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