Ontology highlight
ABSTRACT:
SUBMITTER: Takeshima K
PROVIDER: S-EPMC5428735 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Takeshima Kenichiro K Nishiwaki Yuji Y Suda Yasunori Y Niki Yasuo Y Sato Yuiko Y Kobayashi Tami T Miyamoto Kana K Uchida Hisaya H Inokuchi Wataru W Tsuji Takashi T Funayama Atsushi A Nakamura Masaya M Matsumoto Morio M Toyama Yoshiaki Y Miyamoto Takeshi T
Scientific reports 20170327 1
Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH2*2), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs ...[more]