Targeted drugs for pulmonary arterial hypertension: a network meta-analysis of 32 randomized clinical trials.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a devastating disease and ultimately leads to right heart failure and premature death. A total of four classical targeted drugs, prostanoids, endothelin receptor antagonists (ERAs), phosphodiesterase 5 inhibitors (PDE-5Is), and soluble guanylate cyclase stimulator (sGCS), have been proved to improve exercise capacity and hemodynamics compared to placebo; however, direct head-to-head comparisons of these drugs are lacking. This network meta-analysis was conducted to comprehensively compare the efficacy of these targeted drugs for PAH.

Methods

Medline, the Cochrane Library, and other Internet sources were searched for randomized clinical trials exploring the efficacy of targeted drugs for patients with PAH. The primary effect

SUBMITTER: Gao XF 

PROVIDER: S-EPMC5428768 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature