Ontology highlight
ABSTRACT:
SUBMITTER: Lof L
PROVIDER: S-EPMC5429594 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Löf Liza L Arngården Linda L Olsson-Strömberg Ulla U Siart Benjamin B Jansson Mattias M Dahlin Joakim S JS Thörn Ingrid I Christiansson Lisa L Hermansson Monica M Larsson Anders A Ahlstrand Erik E Wålinder Göran G Söderberg Ola O Rosenquist Richard R Landegren Ulf U Kamali-Moghaddam Masood M
Scientific reports 20170404 1
Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion protein, and minimal residual disease (MRD) after therapy is monitored by real-time quantitative PCR (RQ-PCR) of the fusion transcript. Here, we describe a novel approach to detect an ...[more]