Ontology highlight
ABSTRACT:
SUBMITTER: Khamaysi I
PROVIDER: S-EPMC5429646 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Khamaysi Iyad I Singh Preeti P Nasser Susan S Awad Hoda H Chowers Yehuda Y Sabo Edmond E Hammond Edward E Gralnek Ian I Minkov Irena I Noseda Alessandro A Ilan Neta N Vlodavsky Israel I Abassi Zaid Z
Scientific reports 20170406 1
Acute pancreatitis (AP) is one of the most common diseases in gastroenterology. However, neither the etiology nor the pathophysiology of the disease is fully understood and no specific or effective treatment has been developed. Heparanase is an endoglycosidase that cleaves heparan sulfate (HS) side chains of HS sulfate proteoglycans into shorter oligosaccharides, activity that is highly implicated in cellular invasion associated with cancer metastasis and inflammation. Given that AP involves a s ...[more]