Ontology highlight
ABSTRACT:
SUBMITTER: Beaumont C
PROVIDER: S-EPMC5429715 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Beaumont Catherine C Walsh-Wilkinson Élisabeth É Drolet Marie-Claude MC Roussel Élise É Arsenault Marie M Couet Jacques J
Scientific reports 20170407 1
Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). The ...[more]