Ontology highlight
ABSTRACT:
SUBMITTER: Post M
PROVIDER: S-EPMC5430038 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Post Mirte M Cuapio Angelica A Osl Markus M Lehmann Dorit D Resch Ulrike U Davies David M DM Bilban Martin M Schlechta Bernhard B Eppel Wolfgang W Nathwani Amit A Stoiber Dagmar D Spanholtz Jan J Casanova Emilio E Hofer Erhard E
Frontiers in immunology 20170515
We identified <i>ZNF683/HOBIT</i> as the most highly upregulated transcription factor gene during <i>ex vivo</i> differentiation of human CD34<sup>+</sup> cord blood progenitor cells to CD56<sup>+</sup> natural killer (NK) cells. ZNF683/HOBIT mRNA was preferentially expressed in NK cells compared to other human peripheral blood lymphocytes and monocytes. During <i>ex vivo</i> differentiation, ZNF683/HOBIT mRNA started to increase shortly after addition of IL-15 and further accumulated in paralle ...[more]