Ontology highlight
ABSTRACT:
SUBMITTER: Arakelyan A
PROVIDER: S-EPMC5430429 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Arakelyan Anush A Fitzgerald Wendy W King Deborah F DF Rogers Paul P Cheeseman Hannah M HM Grivel Jean-Charles JC Shattock Robin J RJ Margolis Leonid L
Scientific reports 20170419 1
HIV-1 envelope proteins (Envs) play a critical role in HIV infection. In a correct trimeric conformation, Env mediates virus-cell binding and fusion. Malfunctioning of this machinery renders virions incapable of infecting cells. Each HIV-1 virion carries 10-14 Envs, and therefore a defective Env may not necessarily render a HIV virion non-infectious, since other Env on the same virion may still be functional. Alternatively, it is possible that on a given virion either all the spikes are defectiv ...[more]