Ontology highlight
ABSTRACT:
SUBMITTER: Ietta F
PROVIDER: S-EPMC5430667 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ietta Francesca F Maioli Emanuela E Daveri Elena E Gonzaga Oliveira Juliana J da Silva Rafaela José RJ Romagnoli Roberta R Cresti Laura L Maria Avanzati Anna A Paulesu Luana L Barbosa Bellisa de Freitas BF Gomes Angelica de Oliveira AO Roberto Mineo José J Ferro Eloisa Amália Vieira EAV
Scientific reports 20170428 1
Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of Rottlerin, a natural polyphenol with autophagic promoting properties, against Toxoplasma infection on the chorioncarcinoma-derived cell line BeWo. We found that Rottlerin, at sub-to ...[more]