Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.
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ABSTRACT:
SUBMITTER: Polimanti R
PROVIDER: S-EPMC5430682 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.
Polimanti Renato R Jensen Kevin P KP Gelernter Joel J
Scientific reports 20170421 1
To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We identified a significant association between CYP2A6 rs113288603 and hearing loss symptoms (p = 5.75 × 10<sup>-5</sup>). No association was observed in a sample of 3,245 nicotine-unexpos ...[more]
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