Ontology highlight
ABSTRACT:
SUBMITTER: Arya R
PROVIDER: S-EPMC5430726 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Arya Richa R Dangi Rohit Singh RS Makwana Pinakin K PK Kumar Ambrish A Upadhyay Santosh Kumar SK Upadhyay Santosh Kumar SK Sundd Monica M
Scientific reports 20170428 1
Src homology domain containing leukocyte protein of 65 kDa (SLP65), the growth factor receptor binding protein 2 (Grb2), and the guanine nucleotide exchange factor for the Rho family GTPases (Vav), self associate in unstimulated B cells as components of the preformed B cell receptor transducer module, in an SH3-dependent manner. The complex enables the B cell to promptly respond to BCR aggregation, resulting in signal amplification. It also facilitates Vav translocation to the membrane rafts, fo ...[more]