Liver ER? regulates AgRP neuronal activity in the arcuate nucleus of female mice.

ABSTRACT: Recent work revealed the major role played by liver Estrogen Receptor ? (ER?) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Er?, we here demonstrate that the hepatic ER? is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ER? activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ER? as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.

SUBMITTER: Benedusi V 

PROVIDER: S-EPMC5430776 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature