Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.
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ABSTRACT:
SUBMITTER: Kruger K
PROVIDER: S-EPMC5430803 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.
Krüger Kristi K Wik Elisabeth E Knutsvik Gøril G Nalwoga Hawa H Klingen Tor A TA Arnes Jarle B JB Chen Ying Y Mannelqvist Monica M Dimitrakopoulou Konstantina K Stefansson Ingunn M IM Birkeland Even E Aas Turid T Tobin Nicholas P NP Jonassen Inge I Bergh Jonas J Foulkes William D WD Akslen Lars A LA
Scientific reports 20170424 1
We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n = 103), mRNA microarray data from TCGA (n = 520), METABRIC (n = 1992), and 6 open access breast cancer datasets (n = 1908) were analysed. Patients with Nestin protein expression in tu ...[more]
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