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Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.


ABSTRACT: We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n?=?103), mRNA microarray data from TCGA (n?=?520), METABRIC (n?=?1992), and 6 open access breast cancer datasets (n?=?1908) were analysed. Patients with Nestin protein expression in tumour cells more often had BRCA1 germline mutations (OR 8.7, p?

SUBMITTER: Kruger K 

PROVIDER: S-EPMC5430803 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n = 103), mRNA microarray data from TCGA (n = 520), METABRIC (n = 1992), and 6 open access breast cancer datasets (n = 1908) were analysed. Patients with Nestin protein expression in tu  ...[more]

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