Selective Targeting of Cancer Cells by Oxidative Vulnerabilities with Novel Curcumin Analogs.

ABSTRACT: Recently, research has focused on targeting the oxidative and metabolic vulnerabilities in cancer cells. Natural compounds like curcumin that target such susceptibilities have failed further clinical advancements due to the poor stability and bioavailability as well as the need of high effective doses. We have synthesized and evaluated the anti-cancer activity of several monocarbonyl analogs of curcumin. Interestingly, two novel analogs (Compound A and I) in comparison to curcumin, have increased chemical stability and have greater anti-cancer activity in a variety of human cancer cells, including triple-negative, inflammatory breast cancer cells. In particular, the generation of reactive oxygen species was selective to cancer cells and occurred upstream of mitochondrial collapse and execu

SUBMITTER: Pignanelli C 

PROVIDER: S-EPMC5430918 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature