Ontology highlight
ABSTRACT:
SUBMITTER: Chelakkot C
PROVIDER: S-EPMC5431506 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chelakkot Chaithanya C Ghim Jaewang J Rajasekaran Nirmal N Choi Jong-Sun JS Kim Jung-Hwan JH Jang Myoung Ho MH Shin Young Kee YK Suh Pann-Ghill PG Ryu Sung Ho SH
Scientific reports 20170508 1
Ulcerative colitis is a multi-factorial disease involving a dysregulated immune response. Disruptions to the intestinal epithelial barrier and translocation of bacteria, resulting in inflammation, are common in colitis. The mechanisms underlying epithelial barrier dysfunction or regulation of tight junction proteins during disease progression of colitis have not been clearly elucidated. Increase in phospholipase D (PLD) activity is associated with disease severity in colitis animal models. Howev ...[more]