Ontology highlight
ABSTRACT:
SUBMITTER: Kannan S
PROVIDER: S-EPMC5431542 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kannan Srinivasaraghavan S Pradhan Mohan R MR Tiwari Garima G Tan Wei-Chong WC Chowbay Balram B Tan Eng Huat EH Tan Daniel Shao-Weng DS Verma Chandra C
Scientific reports 20170508 1
Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced ATP noncovalently but were rendered ineffective due to the development of resistance mutations in the kinase domain. These were overcome by the development of covalent inhibitors such as afatinib which also bind in the ATP pocket. However pooled analysis of two ...[more]