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2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications.

ABSTRACT: A novel turn-on two-photon fluorescent probe NS-N ₂ H ₄ was developed with the 2-benzothiazoleacetonitrile as a new recognition site for the detection of hydrazine (N₂H₄). The two-photon probe exhibited favorable properties including high selectivity, low cytotoxicity and almost 16-fold fluorescence enhancement in the presence of N₂H₄ in solution. The probe could be used to image hydrazine in the living cells. Notably, we also used the two-photon fluorescent probe to image hydrazine in the tissue imaging for the first time. Furthermore, by the way of probe-loaded TLC plate, we further monitored vapor of hydrazine. Therefore, the novel two-photon probe is expected to be employed to detect N₂H₄ in biosamples and environmental pollution and the new recognition site will be widely applied to construct fluorescent probes for the detection of N₂H₄.

SUBMITTER: Wang JY

PROVIDER: S-EPMC5431551 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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2-benzothiazoleacetonitrile based two-photon fluorescent probe for hydrazine and its bio-imaging and environmental applications.

Wang Jian-Yong JY Liu Zhan-Rong ZR Ren Mingguang M Lin Weiying W

Scientific reports 20170508 1

A novel turn-on two-photon fluorescent probe NS-N 2 H 4 was developed with the 2-benzothiazoleacetonitrile as a new recognition site for the detection of hydrazine (N2H4). The two-photon probe exhibited favorable properties including high selectivity, low cytotoxicity and almost 16-fold fluorescence enhancement in the presence of N2H4 in solution. The probe could be used to image hydrazine in the living cells. Notably, we also use ...[more]

PMID: 28484214

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