Ontology highlight
ABSTRACT:
SUBMITTER: Lee RFS
PROVIDER: S-EPMC5431558 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lee Ronald F S RFS Chernobrovkin Alexey A Rutishauser Dorothea D Allardyce Claire S CS Hacker David D Johnsson Kai K Zubarev Roman A RA Dyson Paul J PJ
Scientific reports 20170508 1
The emerging technique termed functional identification of target by expression proteomics (FITExP) has been shown to identify the key protein targets of anti-cancer drugs. Here, we use this approach to elucidate the proteins involved in the mechanism of action of two ruthenium(II)-based anti-cancer compounds, RAPTA-T and RAPTA-EA in breast cancer cells, revealing significant differences in the proteins upregulated. RAPTA-T causes upregulation of multiple proteins suggesting a broad mechanism of ...[more]