Ontology highlight
ABSTRACT:
SUBMITTER: Seong J
PROVIDER: S-EPMC5431615 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Seong Jihye J Huang Min M Sim Kyoung Mi KM Kim Hyunbin H Wang Yingxiao Y
Scientific reports 20170509 1
Platelet-derived growth factor receptor (PDGFR) senses extracellular growth factors and transfer the signals inside the cells regulating cell proliferation, migration and survival. It has been controversial at which membrane microdomains PDGFRs reside and how they control such diverse intracellular signaling pathways. Here, we developed a novel PDGFR biosensor based on fluorescence resonance energy transfer (FRET), which can detect the real-time PDGFR activity in live cells with high spatiotempo ...[more]