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Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides.


ABSTRACT: A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(ii)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology.

SUBMITTER: Williamson P 

PROVIDER: S-EPMC5431632 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides.

Williamson Patrick P   Galván Alicia A   Gaunt Matthew J MJ  

Chemical science 20170110 4


A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(ii)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed <i>via</i> this methodology. ...[more]

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