Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5431654 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Liu Yang Y Zhang Zhong Z Liang Hui H Zhao Xuyang X Liang Ling L Wang Guangxi G Yang Jingyi J Jin Yan Y McNutt Michael A MA Yin Yuxin Y
Scientific reports 20170509 1
EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives bipolar spindle formation. EG5 provides power for spindle movement and thus controls the dynamics of spindle assembly. However, little is known about EG5 regulation or how EG5 detaches from the spindle upon mitotic exit. In this study we identify E ...[more]