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Efficient Antibacterial Membrane based on Two-Dimensional Ti₃C₂T_x (MXene) Nanosheets.

ABSTRACT: Advanced membranes that enable ultrafast water flux while demonstrating anti-biofouling characteristics can facilitate sustainable water/wastewater treatment processes. MXenes, two-dimensional (2D) metal carbides and nitrides, have attracted attention for applications in water/wastewater treatment. In this work, we reported the antibacterial properties of micrometer-thick titanium carbide (Ti₃C₂T_x) MXene membranes prepared by filtration on a polyvinylidene fluoride (PVDF) support. The bactericidal properties of Ti₃C₂T_x modified membranes were tested against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) by bacterial growth on the membrane surface and its exposure to bacterial suspensions. The antibacterial rate of fresh Ti₃C₂T_x MXene membranes reaches more than 73% against B. subtilis and 67% against E. coli as compared with that of control PVDF, while aged Ti₃C₂T_x membrane showed over 99% growth inhibition of both bacteria under same conditions. Flow cytometry showed about 70% population of dead and compromised cells after 24?h of exposure of both bacterial strains. The damage of the cell surfaces was also revealed by scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis, respectively. The demonstrated antibacterial activity of MXene coated membranes against common waterborne bacteria, promotes their potential application as anti-biofouling membrane in water and wastewater treatment processes.

SUBMITTER: Rasool K

PROVIDER: S-EPMC5431673 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Efficient Antibacterial Membrane based on Two-Dimensional Ti3C2Tx (MXene) Nanosheets.

Rasool Kashif K Mahmoud Khaled A KA Johnson Daniel J DJ Helal Mohamed M Berdiyorov Golibjon R GR Gogotsi Yury Y

Scientific reports 20170509 1

Advanced membranes that enable ultrafast water flux while demonstrating anti-biofouling characteristics can facilitate sustainable water/wastewater treatment processes. MXenes, two-dimensional (2D) metal carbides and nitrides, have attracted attention for applications in water/wastewater treatment. In this work, we reported the antibacterial properties of micrometer-thick titanium carbide (Ti3C2Tx) MXene membranes prepared by filtration on a polyvinylidene fluori ...[more]

PMID: 28487521

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Project description:BackgroundTwo-dimensional ultrathin Ti3C2 (MXene) nanosheets have been extensively explored for various biomedical applications. However, safety issues and the effects of Ti3C2 on human health remain poorly understood.ResultsTo explore the influence on foetal or offspring after exposure to Ti3C2 nanosheets, we established a mouse model exposed to different doses of Ti3C2 nanosheets during early pregnancy in this study. We found that Ti3C2 nanosheets had negligible effect on the reproductive ability of maternal mice, including average pregnancy days, number of new-borns, and neonatal weight, etc. Unexpectedly, abnormal neurobehavior and pathological changes in the cerebral hippocampus and cortex in adult offspring were observed following Ti3C2 nanosheet treatment. In further studies, it was found that Ti3C2 exposure led to developmental and functional defects in the placenta, including reduced area of labyrinth, disordered secretion of placental hormones, and metabolic function derailment. The long-chain unsaturated fatty acids were significantly higher in the placenta after Ti3C2 exposure, especially docosahexaenoic acid (DHA) and linoleic acid. The metabolic pathway analysis showed that biosynthesis of unsaturated fatty acids was upregulated while linoleic acid metabolism was downregulated.ConclusionsThese developmental and functional defects, particularly metabolic function derailment in placenta may be the cause for the neuropathology in the offspring. This is the first report about the effects of Ti3C2 nanosheet exposure on pregnancy and offspring. The data provides a better understanding of Ti3C2 nanosheets safety. It is suggested that future studies should pay more attention to the long-term effects of nanomaterials exposure, including the health of offspring in adulthood, rather than only focus on short-term effects, such as pregnancy outcomes. Metabolomics could provide clues for finding the prevention targets of the biological negative effect of Ti3C2 nanosheets.

Dataset Information

Efficient Antibacterial Membrane based on Two-Dimensional Ti₃C₂T_x (MXene) Nanosheets.

Publications

Efficient Antibacterial Membrane based on Two-Dimensional Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> (MXene) Nanosheets.

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