The molecular basis of thin filament activation: from single molecule to muscle.
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ABSTRACT:
SUBMITTER: Longyear T
PROVIDER: S-EPMC5431769 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
The molecular basis of thin filament activation: from single molecule to muscle.
Longyear Thomas T Walcott Sam S Debold Edward P EP
Scientific reports 20170512 1
For muscles to effectively power locomotion, trillions of myosin molecules must rapidly attach and detach from the actin thin filament. This is accomplished by precise regulation of the availability of the myosin binding sites on actin (i.e. activation). Both calcium (Ca<sup>++</sup>) and myosin binding contribute to activation, but both mechanisms are simultaneously active during contraction, making their relative contributions difficult to determine. Further complicating the process, myosin bi ...[more]
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