Ontology highlight
ABSTRACT:
SUBMITTER: Caldieri G
PROVIDER: S-EPMC5432029 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Caldieri Giusi G Barbieri Elisa E Nappo Gilda G Raimondi Andrea A Bonora Massimo M Conte Alexia A Verhoef Lisette G G C LGGC Confalonieri Stefano S Malabarba Maria Grazia MG Bianchi Fabrizio F Cuomo Alessandro A Bonaldi Tiziana T Martini Emanuele E Mazza Davide D Pinton Paolo P Tacchetti Carlo C Polo Simona S Di Fiore Pier Paolo PP Sigismund Sara S
Science (New York, N.Y.) 20170501 6338
The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We identified NCE-specific regulators, including the endoplasmic reticulum (ER)-resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critica ...[more]