Ontology highlight
ABSTRACT:
SUBMITTER: Karathedath S
PROVIDER: S-EPMC5432104 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Karathedath Sreeja S Rajamani Bharathi M BM Musheer Aalam Syed Mohammed SM Abraham Ajay A Varatharajan Savitha S Krishnamurthy Partha P Mathews Vikram V Velayudhan Shaji Ramachandran SR Balasubramanian Poonkuzhali P
PloS one 20170515 5
Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. NF-E2 related factor-2 (Nrf2), a master regulator of antioxidant response is implicated in chemoresistance in solid tumors. However, little is known about the role of Nrf2 in AML chemoresistance and the effect of pharmacological inhibitor brusatol in modulating ...[more]