Ontology highlight
ABSTRACT:
SUBMITTER: Germano G
PROVIDER: S-EPMC5432245 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Germano Giuseppe G Morello Giulia G Aveic Sanja S Pinazza Marica M Minuzzo Sonia S Frasson Chiara C Persano Luca L Bonvini Paolo P Viola Giampietro G Bresolin Silvia S Tregnago Claudia C Paganin Maddalena M Pigazzi Martina M Indraccolo Stefano S Basso Giuseppe G
Oncotarget 20170401 16
Zinc finger protein 521 (ZNF521) is a multiple zinc finger transcription factor and a strong candidate as regulator of hematopoietic stem cell homeostasis. Recently, independent gene expression profile studies have evidenced a positive correlation between ZNF521 mRNA overexpression and MLL-rearranged acute myeloid leukemia (AML), leaving open the question on the role of ZNF521 in this subtype of leukemia. In this study, we sought to analyze the effect of ZNF521 depletion on MLL-rearranged AML ce ...[more]